When multiple cannabis molecules are integrated, their potential therapeutic effects can be altered or enhanced. Flavor and psychoactive potential can also be affected, creating different products with different properties.

According to proponents, the group dynamics of the entourage effect can create emergent properties that would not otherwise be present in pure THC or CBD crystals.

Many, who work closely with cannabis, believe that the entourage effect can dramatically increase the potential therapeutic properties of THC and CBD, among others, either by increasing their known effects or by expanding their menu of therapeutic uses. The potential therapeutic effects of cannabis molecules stem from their ability to bind to naturally occurring Endo-CannaBinoid receptors in the brain and throughout the central nervous system. The human Endo- CannaBinoïDen system is designed to bind to endogenous cannabinoids produced by the body, but compounds found in cannabis plants can bind to these receptors just as efficiently.

There are numerous health benefits when high-quality medicinal cannabis is consumed by people. The entourage effect may be one reason why marijuana can be such an effective potential medicine.